The majority of toxicity from the cytokine storm appears to be from antibodies, causing anaphylactic shock and a toxic product, peroxynitrite.
The former is generated from the Th1 lymphocytes; the latter is generated from the enzymes Xanthine Oxidase, creating an oxygen radical (called superoxide) and the enzyme inducible Nitric Oxide Synthase (generating nitric oxide). The product generated from O2- and NO is “peroxynitrite’. This toxin is reduced by the enzyme glutathione peroxidase, formed from glutathione and selenium.
Blocking/reducing the toxicity:
Omega 3 fatty acids over 3 grams/day will dramatically reduce the TH1 lymphocytes. Since the Th1 lymphocytes are also important in antiviral activity, general antioxidants such as Vitamin E, Vitamin C, and flavonoids are helpful at inhibiting NFKappa B, which is responsible for many viral replications.
High dose fish oil is NOT recommended in acute viral infections, however it prevents cytokine storm in post vaccine viral challenge. (When omega 3 is not used as a pretreatment, acute toxicity must be treated with prednisone.)
Xanthine Oxidase inhibition: Cherry extract and most flavonoid nutrients will inhibit Xanthine oxidase. (Allopurinol is contraindicated as it generates radicals during its metabolism.) 2 capsules, 2x/day is effective.
Inducible Nitric Oxide Synthase (iNOS): Nicotinamide 500 mg 2-3 per day is effective in down regulating iNOS and TNFalpha (Tumor Necrosing factor alpha).
Glutathione Peroxidase: Consists of cysteine, the amino acid, and selenium as a trace mineral.
N-acetyl cysteineL 200 mg/day (Also found in chicken, turkey, yogurt, egg, garlic and cheeses are high in cysteine.)
Selenium: 100 mcg/day as selenomethione or sodium selenite. (Also found in Brazil nuts, chicken fish shellfish and eggs.)
Peroxynitrite inhibition: Methionine, 500 mg 2 times per day. (Thiols, ebselen, methionine, tyrosine and ascorbate.)
Caution: Red meat and high iron foods are contraindicated as they will enhance the toxicity of TH1 antibodies and Peroxynitrite.
General anti-inflammatory natural compounds: ECGC, green tea (which downregulates IL-6); also curcumin, sulforaphanes, resveratrol (which activate the anti-inflammatory Nrf2. The endogenous anti-inflammatory Nrf2 is downregulated in viral diseases.
The combination above has been shown to reverse rheumatoid arthritis in 4 weeks with fish oil and reverse pancreatitis in 24 hours. The antioxidant system has cured Epstein Barr (EBV) Hepatosplenomegaly and Herpes VI Hepatosplenomegaly within 24 – 48 hour and dramatically decreased the toxicity in Hepatitis infections within days, prevented toxicity in ARDS, and reversed AIDS to regrowth of lymphocytes in HIV positive without progression to AIDS.
Prof (hon) Dr. Dana F. Flavin, Dr. med univ, N.D., M.S.,
Physician, Pharmacologist, Biochemist, Toxicologist
Former Science Assistant to the Associate Bureau Director, Toxicology, F.D.A.
President: The Foundation for Collaborative Medicine and Research, www.collmed.org